It is estimated that about 50% of patients with locally advanced stages of head and neck carcinoma will develop loco-regional or distant recurrences, mostly during the first 2 years of follow-up [1].

Breast cancer(BC) is described as a malignant development that occurs in the structure of the mammary gland. BC is the most common cancer in women. It is the major causes of death from cancer. We present a 62-years-old femalepatient had left radical mastectomy + axillary lymphnode curettage with a diagnosis of stage IIIA invasive ductal breast cancer 10 years ago. After adjuvant oncological treatment recurrence was detected in the chest wall. She successful operated with hybrid reconstruction using both synthetic and autologous grafts.

Kimura disease is a chronic inflammatory disease, which frequently affects middle-aged Asian men, although children are seldom affected by it. This may rarely be encountered in children, and the knowledge of this fact is essential to rule out the remote possibility of Kimura’s disease in children with a slow-growing painless mass in the head and neck region. Therefore, the characteristics of the Kimura disease of childhood have not been well illustrated. Here we are reporting 2 cases of Kimura disease in 17 years & 22 years old female. (Head and neck are the most frequently involved sites of subcutaneous masses). On laboratory investigations, in both the patients are having peripheral blood eosinophilia and elevated immunoglobulin E level were seen. Clinicians need to be aware of this disease when dealing with patients with lymphadenopathy. A standard and effective treatment protocol would improve the outcome of the Kimura disease. Here we report a case of Kimura disease in rare age group.

A 10-year-old male patient visited the department of oral medicine and radiology with a chief complaint of pain and swelling on right side of the face. A patient gave the history of swelling on right side of lower 1/3rd of face since 7-8 years with dull, intermittent pain which aggravates on taking food for 1 month. The patient had undergone radiographic investigations and biopsy on the right side of face 15 days back. On extra oral examination, swelling on right side of lower1/3rd of face extending anteroposteriorly from a straight line drawn from inner canthus of the eye, posteriorly 1 cm beyond outer canthus of the eye. Supero-inferiorly from a straight line drawn from commissure of the lip to 1 cm beyond the inferior border of mandible. Swelling is approximately 4x4 cm in size. The overlying skin has increase pigmentation with sinus opening, tender on palpation, bony hard. Right sub mandibular lymph node palpable, mobile and tender. On intra-oral examination, obliteration of vestibule from 44 to 47. The provisional diagnosis of chronic suppurative osteomyelitis. OPG reveals dense, homogeneous radio-opaque mass on right side of the body with surrounding radiolucent halo extending from 44 to 47. Supero-inferiorly from the superior border of the mandible to the inferior border of the mandible to the inferior border of the mandible with multiple tooth-like structures at the inferior border of the mandible. There is thinning of the inferior cortex of mandible with a divergence of 43, 44, and 47. CECT reveals a well define lobulated mass with few hypodense areas, measures approximately 37x36x29 mm. the mass is causing significant bi-cortical expansion of mandible. Radiographic diagnosis- odontomas. Excisional biopsy was performed and a histopathologic diagnosis was COMPOUND COMPOSITE ODONTOME.

Cancer has for long been classified as having origin in a type of cell or tissue and has for ages been considered as a result from a single tumor cell. With the advances in genomics, transcriptomic and epigenetic research, cancer has now been recognized as a heterogeneous disease within itself. This enables clonal survival and resistance to therapies. However, cancer and inflammation have walked side by side for decades. The real knowledge of its interactions between the immunological system and carcinogenesis is yet to be wholly understood. Much has been discovered on how these interactions occur, how they differ in an intratumoral context and with the direct influence of the micoenvironment.

Background: Bleeding under hepatic capsule resulting from spontaneous rupture of hepatocellular carcinoma (HCC) is an uncommon episode in clinical practice, which may lead to the potential of lethal consequence. However, the fact not sure what to prefer to conduct when facing upcoming rupture of the liver true capsule. Objective: Aims to identify the cause of tumor rupture and to judge the proper timing for surgery. Methods: We described a 53-year-old man, who was hospitalized with the misdiagnosis of acute cholecystitis and gallstone, which accurately was triggered by occult bleeding of a nodular regenerative hyperplasia under hepatic capsule closer to the gallbladder. He experienced a series of urgent rescue measures (cardiopulmonary cerebral resuscitation (CPCR), transcatheter arterial embolization (TAE) and laparotomy in turn). Results: Unfortunately, he died of liver failure, kidney failure and cerebral hemorrhage. Conclusion: Herb may induce tumor necrosis or bleeding. The proper time for surgery and the optimized strategy in this case are of crucial importance to save one’s life.